Requirements: * Bitcoin >=0.5.0 * Python * Twisted * python-argparse (for Python <=2.6) Linux: sudo apt-get install python-zope.interface python-twisted python-twisted-web sudo apt-get install python-argparse # if on Python 2.6 or older Windows: Install Python 2.7: http://www.python.org/getit/ Install Twisted: http://twistedmatrix.com/trac/wiki/Downloads Install Zope.Interface: http://pypi.python.org/pypi/zope.interface/3.8.0 unzip the files into C:\Python27\Lib\site-packages To use p2pool, you must be running your own local bitcoind. p2pool connects to this bitcoin over both its p2p interface and its RPC interface. For standard configurations, using p2p should be as simple as: python run_p2pool.py Then run your miner program, connecting to 127.0.0.1 on port 9332 with any username and password. If you are behind a NAT, it will help to enable TCP port forwarding on your router. Forward port 9333 to the host running p2pool.py. Use python run_p2pool.py --help for additional options.